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Transforming Neurological Care

Transforming Neurological CareTransforming Neurological CareTransforming Neurological Care

Neurological Disorders by the Numbers

1 Billion

$1.6 Trillion

6.8 Million

People with Neurological 

Disorders Globally

6.8 Million

$1.6 Trillion

6.8 Million

Deaths from Neurological 

Disorders each Year

$1.6 Trillion

$1.6 Trillion

$1.6 Trillion

Combined Economic Burden in Europe and the USA alone 

The PROBLEM

Lack of Biomarkers

Most brain disorders lack a biomarker (i.e, a way to measure disease progression).  As a result, clinicians rely on subjective scales to measure efficacy of treatment which typically result in increased costs, poor patient outcomes, and years of time spent trying to find the right treatment.   

Increased Costs while outcomes stagnant

A recent study showed that in the USA, direct costs related to Epilepsy have almost doubled in the last decade to $28B per year, while outcomes have not improved in almost three decades.

The Parents' Perspective

For Patients, it is even more difficult to be the 'eyes' of the clinicians outside of the clinic, particularly in trying to keep track of disease progression given the lack of knowledge of what to look for and if they are doing it well.  Hear the perspective of Amy and David - parents of a child diagnosed with epilepsy. 

The solution

Eysz is building a passive neurological exam using real world data.  By leveraging oculometric data from consumer grade eye-tracking systems, our software algorithms have the potential to reliably detect consciousness and other neurological 'vital signs' such as cognition and mood.  While our initial focus will be Epilepsy, our aim is to expand to other neurological disorders.   

The Potential Benefits

Improving Outcomes

Improving Quality of Life

Improving Quality of Life

By helping clinicians get the data they need to identify the right treatments sooner. 

Improving Quality of Life

Improving Quality of Life

Improving Quality of Life

Relieving patients and caregivers from the burden of self-reporting.

Reducing Costs

Improving Quality of Life

Reducing Costs

Reduce the number of costly visits to the hospital.

The Evidence

Proof of Concept: Completed

We completed a 30 patient proof-of-concept study which demonstrated that eye-tracking could be used to detect the subtlest seizure type, absence seizures.

DASEY Study (Ictal): Completed

Detecting Absence Seizures using Eye-tracking (DASEY):  We have completed an in-depth clinical study supported by an NIH Phase 1 SBIR Grant involving 4 Level 4 Epilepsy Centers to analyze ictal eye-movement data and develop algorithms.

DASEY Study (Interictal): Completed

Supported by an NSF Phase 1 SBIR Grant we analyzed interictal eye-movement data and were able to show a correlation to subjects having active seizures. 

DASHER Study: Planning

We have been awarded an NIH SBIR Phase I grant to compare the accuracy of 3 epileptologists reading a smartphone video recording during hyperventilation to 3 epileptologists reading the corresponding video EEG during hyperventilation.  Stay tuned for more information on this study!

ACER Study: Planning

We have been awarded an SBIR Phase II grant from the National Science Foundation (NSF) for assessing comorbidities in epilepsy using eye movement recordings.  Stay tuned for more information on this study!

Our Team

Rachel Kuperman, MD, Founder & CEO

Parth Amin, Co-Founder and COO

Parth Amin, Co-Founder and COO

Neurologist with dual certification in epilepsy and neurology with over 10 years’ experience directing the clinical epilepsy and research programs at UCSF Benioff Children’s Hospital, Oakland

Parth Amin, Co-Founder and COO

Parth Amin, Co-Founder and COO

Parth Amin, Co-Founder and COO

Leads our Product Development efforts and GTM Strategy.  Brings 15+ Years Medical Device Experience in Product and Project Management, Product Launch, and Alliances having worked at Siemens Healthineers, Varian, and Omnicell. 

Jit Sarkar, PhD, Co-Founder and CTO

Parth Amin, Co-Founder and COO

Jit Sarkar, PhD, Co-Founder and CTO

Leads our eye-tracking research efforts . He completed his undergraduate degree in computer science and has deep experience applying machine learning methods. His PhD from UCSD focused on extracting signals from a complex medium.

Nate Blanco, Phd Data Scientist

Ying Yu, Phd Data Science Fellow

Jit Sarkar, PhD, Co-Founder and CTO

Leads the design and implementation efforts for our eye-tracking data science experiements.  Brings experience in research, statistical analysis, and computational modeling in the field of cognitive neurosicience —most recently as a postdoctoral researcher in the Cognitive Development Lab at the Ohio State University.  

Meghan Combs, Product Manager

Ying Yu, Phd Data Science Fellow

Ying Yu, Phd Data Science Fellow

Oversees our product lifecycle and ensures the voice of the customer is represented throughout.  Brings 5+ years experience in product management and quality assurance for software based solutions.

Ying Yu, Phd Data Science Fellow

Ying Yu, Phd Data Science Fellow

Ying Yu, Phd Data Science Fellow

Supports the diesign and implementation of our eye-tracking data science experiments.   Completed her Ph.D. from The Ohio State University in cognitive psychology, focusing on visual perception research with psychophysics and statistical modeling.

Our Advisors

Robert Fisher, MD, PhD Scientific Advisor

Robert Fisher, MD, PhD Scientific Advisor

Robert Fisher, MD, PhD Scientific Advisor

Dr. Fisher is Maslah Saul MD Professor and Director of the Stanford  Epilepsy Center. He had research awards from the Klingenstein  Foundation, EF, CURE and NIH. He published 160 peer-reviewed articles  and 4 books. He was named 1996-2016 in Best Doctors in America.  Dr. Fisher is Past-President of the American Epilepsy  Society, and has 

Dr. Fisher is Maslah Saul MD Professor and Director of the Stanford  Epilepsy Center. He had research awards from the Klingenstein  Foundation, EF, CURE and NIH. He published 160 peer-reviewed articles  and 4 books. He was named 1996-2016 in Best Doctors in America.  Dr. Fisher is Past-President of the American Epilepsy  Society, and has served on the Board of the ILAE and as Editor-in-Chief  of the Journal, Epilepsia.  His research is on new devices to treat epilepsy.   

Hal Blumenfeld, MD, PhD Scientific Advisor

Robert Fisher, MD, PhD Scientific Advisor

Robert Fisher, MD, PhD Scientific Advisor

Dr. Blumenfeld's clinical and research work focuses on epilepsy, cognition and brain  imaging. He directs Yale's Clinical Neuroscience Imaging Center (CNIC), a  new multi-disciplinary core facility for innovative study and treatment  of brain disorders. Teaching activities include a textbook titled  Neuroanatomy Through Clinical Cases, Sinauer Assoc., Publ. 2002, 2010. 

Nicolle Napier-Ionascu, PsyD Scientific Advisor

Nicolle Napier-Ionascu, PsyD Scientific Advisor

Nicolle Napier-Ionascu, PsyD Scientific Advisor

Practicing neuropsychology for over 12 years. She is also the head Neuropsychologist in the Epilepsy department at UCSF Benioff Children’s Hospital Oakland.  

Peter Milford, PhD Technical Advisor

Nicolle Napier-Ionascu, PsyD Scientific Advisor

Nicolle Napier-Ionascu, PsyD Scientific Advisor

Dr. Milford has over 15 years experience in developing high technology instrumentation. He was CTO of Eyefluence, which was developing the next generation eye-tracking wearable technology,  up until October 2016, when purchased by Google. He  continued to develop eye interaction and eye tracking for augmented reality (AR) and virtual real

Dr. Milford has over 15 years experience in developing high technology instrumentation. He was CTO of Eyefluence, which was developing the next generation eye-tracking wearable technology,  up until October 2016, when purchased by Google. He  continued to develop eye interaction and eye tracking for augmented reality (AR) and virtual reality (VR) headsets.  He now serves as the President of Parallel Rules consulting firm.  

Board

Randy Berholtz JD, MBA

Randy Berholtz JD, MBA

Randy Berholtz JD, MBA

Randy leverages his corporate experience, where he has held roles as a corporate and business development executive and as general counsel, to help nurture over 25 startups in healthcare from funding, to serving as a board of director to corporate and business development and strategic initiatives.  He currently serves as a Partner for Ve

Randy leverages his corporate experience, where he has held roles as a corporate and business development executive and as general counsel, to help nurture over 25 startups in healthcare from funding, to serving as a board of director to corporate and business development and strategic initiatives.  He currently serves as a Partner for Ventac Partners and a Senior Advisor for Mesa Partners.  He is also a parent of a child with epilepsy.

Colin Lake

Randy Berholtz JD, MBA

Randy Berholtz JD, MBA

Colin is the Head of Digital Transformation Neurology at UCB Pharma, the global leaders in the field of epilepsy research and medicine development. Colin brings decades of global executive experience in pharma and digital health innovation. In his current role, Colin spearheads UCB’s efforts to improve the support for patients and key sta

Colin is the Head of Digital Transformation Neurology at UCB Pharma, the global leaders in the field of epilepsy research and medicine development. Colin brings decades of global executive experience in pharma and digital health innovation. In his current role, Colin spearheads UCB’s efforts to improve the support for patients and key stakeholders in the healthcare ecosystem by driving UCB’s ambitious digital agenda. While currently living in the U.S., Colin is originally from the U.K. and has been fortunate enough to live and work in seven different countries.

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